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Wagner AD, Maril A, Schacter DL.

Interactions Between Forms of Memory: When Priming Hinders New Episodic Learning

fMRIDC Accession Number: 2-2000-11142
Journal of Cognitive Neuroscience 2000 Nov ;12(suppl. 2): p.52-60
PubMed ID: 11506647 (off-site link)
 Study Meta-Data
NIA grant number 5F32AG005778-02

Human memory consists of multiple forms, including priming and explicit memory. Although considerable evidence indicates that priming and explicit memory is functionally and neuroanatomically distinct, little is known about when and how these different forms of memory interact. Here, behavioral and functional magnetic resonance imaging (fMRI) methods were used to examine a novel and counterintuitive hypothesis: Priming during episodic encoding may be negatively associated with subsequent explicit memory. Using as experimental design that exploited known properties of spacing or lag effects the magnitudes of behavioral and neural priming during a second study episode were varied and relation between these magnitudes of priming during re-encoding and performance on a subsequent explicit memory test was examined. Results revealed that greater behavioral priming (reduced reaction times) and neural priming (reduced left inferior prefrontal rain activation) during re-encoding were associated with lower levels of subsequent explicit memory. Moreover, those subjects who demonstrated greater behavioral and neural priming effects during re-encoding following a long-lag tended to demonstrate the least benefit in subsequent explicit memory due to this second study episode. These findings suggest that priming for past experiences can hinder new episodic encoding.

Supplemental Information

Language: English
fMRIDC Comments: Memory priming in episodic learning Dataset Size: 1.6M Available on 3 CDs
Country: USA
Magnetic Field Strength: 3.0T
Scanner Manufacturer: GE Signa ANMR
Analysis Software: Custom
Cognitive Domain: Memory
Subjects: 12
Age Range: 18-27
Functional Runs: 7
Has anatomical data
Has behavioral data
Has raw image data
Has high-res images
Has preprocessed image data

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