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Head, D, Synder, AZ, Girton, LE, Morris, JC, Buckner, RL.
Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease
fMRIDC Accession Number: 2-2004-1168X
Cerebral Cortex 2004 Sep ;: p.
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(off-site link)
PubMed ID:
15371293
(off-site link)
Study Meta-Data
Controversy persists regarding whether Alzheimer's disease (AD) is a distinct entity or instead exists on a continuum with nondemented aging. To explore this issue, volumetric analyses of callosal and hippocampal regions were performed on 150 participants aged 18-93 years. Group-level analyses revealed that nondemented age-related differences were greater in anterior than posterior callosal regions and were not augmented by early-stage AD. In contrast, early-stage AD was associated with substantial reduction in hippocampal volume. Examination of the 100 older adults using regression analyses demonstrated age-associated differences in callosal volume that were similar in demented and nondemented individuals. Early-stage AD was again characterized by a marked reduction in hippocampal volume while age alone induced only mild differences in hippocampal volume. As a final analysis, the formal double dissociation was confirmed by comparing the effects of age directly against the effects of dementia. These results suggest a multiple-component model of aging. One process, associated with AD, manifests early and prominently in the medial temporal lobe. A separate process, ubiquitous in aging, affects brain white matter with an anterior-to-posterior gradient and may underlie the executive difficulties common in aging.
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Supplemental Information
Language: English
Country: USA
Magnetic Field Strength: 1.5 Tels
Scanner Manufacturer: Siemens Vision
Analysis Software: custom
Subjects: 150
Age Range: 18-93
Has anatomical data
Has raw image data
Has high-res images
Published Figure Information
10-19 years
30-39 years
70-79 years
90-99 years
20-29 years
60-69 years
80-89 years
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10-19 years
60-69 years
80-89 years
20-29 years
70-79 years
90-99 years
30-39 years
Comments on Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease
by
interch
on December 17, 2004 @16:50
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