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Head, D, Synder, AZ, Girton, LE, Morris, JC, Buckner, RL.

Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease

fMRIDC Accession Number: 2-2004-1168X
Cerebral Cortex 2004 Sep ;: p.
View entire article (off-site link)
PubMed ID: 15371293 (off-site link)

Study Meta-Data

Controversy persists regarding whether Alzheimer's disease (AD) is a distinct entity or instead exists on a continuum with nondemented aging. To explore this issue, volumetric analyses of callosal and hippocampal regions were performed on 150 participants aged 18-93 years. Group-level analyses revealed that nondemented age-related differences were greater in anterior than posterior callosal regions and were not augmented by early-stage AD. In contrast, early-stage AD was associated with substantial reduction in hippocampal volume. Examination of the 100 older adults using regression analyses demonstrated age-associated differences in callosal volume that were similar in demented and nondemented individuals. Early-stage AD was again characterized by a marked reduction in hippocampal volume while age alone induced only mild differences in hippocampal volume. As a final analysis, the formal double dissociation was confirmed by comparing the effects of age directly against the effects of dementia. These results suggest a multiple-component model of aging. One process, associated with AD, manifests early and prominently in the medial temporal lobe. A separate process, ubiquitous in aging, affects brain white matter with an anterior-to-posterior gradient and may underlie the executive difficulties common in aging.

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Supplemental Information

Language: English
Country: USA
Magnetic Field Strength: 1.5 Tels
Scanner Manufacturer: Siemens Vision
Analysis Software: custom
Subjects: 150
Age Range: 18-93
Has anatomical data
Has raw image data
Has high-res images

Published Figure Information

10-19 years	30-39 years	70-79 years	90-99 years
20-29 years	60-69 years	80-89 years

Download Dataset Images

10-19 years	60-69 years	80-89 years
20-29 years	70-79 years	90-99 years
30-39 years

Comments on Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease by interch on March 30, 2009 @18:04

[ Reply ]

Re: Comments on Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease by Enamul on December 24, 2008 @03:36	[ Reply ]
I've seen all the data are anatomical/structural; Where the functional EPI data? Plz let me informed if anyone can tell something about the matter. I need the functional data.

Re: Comments on Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease by Flavio on March 30, 2009 @18:07	[ Reply ]
I've been trying downloading the images, but the link doesn't works. Please, could you check if there would be a problem with ftp server?

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